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Article

Expression of integrated hepatitis B virus X variants in human hepatocellular carcinomas and its significance.

Biochemical and biophysical research communications - 5 Oct 2000

Chen W N, Oon C J, Leong A L, Koh S, Teng S W

Abstract excerpt

Hepatitis B virus X protein (HBX) has been implicated in the transactivation of diverse cellular genes and possibly also the pathogenesis of human hepatocellular carcinoma (HCC). We report the characterization of HBX variants from HBV-related human hepatocellular carcinoma (HCC). These HBX variants were integrated into the host chromosomes and also expressed in the HCC tissues. In addition, we report a novel in...

Topics

Amino Acid Sequence
Amino Acid Substitution
Carcinoma, Hepatocellular
Cell Extracts
DNA-Binding Proteins
Early Growth Response Protein 1
Gene Expression Regulation, Viral
Genes, Reporter
Genetic Variation
Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immediate-Early Proteins

Liver Neoplasms

Molecular Sequence Data

Mutation

Protein Biosynthesis

RNA, Messenger

RNA, Viral

Source

Identifiers

PMID: 11027564
DOI: 10.1006/bbrc.2000.3562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11027564-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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