Article
Expression of integrated hepatitis B virus X variants in human hepatocellular carcinomas and its significance.
Biochemical and biophysical research communications - 5 Oct 2000
Chen W N, Oon C J, Leong A L, Koh S, Teng S W
Abstract excerpt
Hepatitis B virus X protein (HBX) has been implicated in the transactivation of diverse cellular genes and possibly also the pathogenesis of human hepatocellular carcinoma (HCC). We report the characterization of HBX variants from HBV-related human hepatocellular carcinoma (HCC). These HBX variants were integrated into the host chromosomes and also expressed in the HCC tissues. In addition, we report a novel in...
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