Article
Recombinant ATM protein complements the cellular A-T phenotype.
Oncogene - 10 Jul 1997
Ziv Y, Bar-Shira A, Pecker I, Russell P, Jorgensen T J, Tsarfati I, Shiloh Y
Abstract excerpt
Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by neurodegeneration, immunodeficiency, cancer predisposition, genome instability and radiation sensitivity. The cellular phenotype of A-T points to defects in signal transduction pathways involved in activation of cell cycle checkpoints by free radical damage, and other pathways that mediate the transmission of specific mitogenic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
