Article
Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor.
Neuroreport - 27 May 1997
Rietschel M, Naber D, Fimmers R, Möller H J, Propping P, Nöthen M M
Abstract excerpt
In the present study we tested the hypothesis that individual response to clozapine treatment and/or the occurrence of side-effects may be influenced by genetic variation in the serotonin 5-HT2C receptor. We investigated the frequency of a common Cys23Ser substitution, which is known to alter the...
Topics
- Adult
- Alleles
- Antipsychotic Agents
- Clozapine
- Female
- Genotype
- Humans
- Male
- Mutation
- Polymerase Chain Reaction
- Psychotic Disorders
- Receptors, Serotonin
- Schizophrenia
- Seizures
- Weight Gain