Article
Clozapine response and the 5HT2C Cys23Ser polymorphism.
Neuroreport - 2 Sept 1996
Malhotra A K, Goldman D, Ozaki N, Rooney W, Clifton A, Buchanan R W, Breier A, Pickar D
Abstract excerpt
The presence of the 5HT2C receptor allele, Ser23, has recently been reported to predict favorable response to the antipsychotic drug, clozapine. This finding is of interest as Ser23, compared with the more abundant Cys23, alters pharmacological characteristics of the receptor and therefore may pr...
Topics
- Alleles
- Antipsychotic Agents
- Base Sequence
- Clozapine
- Cysteine
- DNA Primers
- Female
- Genetic Carrier Screening
- Homozygote
- Humans
- Male
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Predictive Value of Tests
- Psychotic Disorders
- Receptor, Serotonin, 5-HT2C
- Receptors, Serotonin
- Schizophrenia