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Article

Clozapine response and the 5HT2C Cys23Ser polymorphism.

Neuroreport - 2 Sept 1996

Malhotra A K, Goldman D, Ozaki N, Rooney W, Clifton A, Buchanan R W, Breier A, Pickar D

Abstract excerpt

The presence of the 5HT2C receptor allele, Ser23, has recently been reported to predict favorable response to the antipsychotic drug, clozapine. This finding is of interest as Ser23, compared with the more abundant Cys23, alters pharmacological characteristics of the receptor and therefore may provide insights into the mechanism of action of antipsychotic drugs. We determined 5HT2C receptor genotype at the...

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Source

Identifiers

PMID: 8930967
DOI: 10.1097/00001756-199609020-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Clozapine response and the 5HT2C Cys23Ser polymorphism.PMID 8930967Read ↗

Efficacy and side-effects of clozapine not associated with variation in the 5-HT2C receptor.Semantic proximity Read ↗

Association between clozapine response and allelic variation in the 5-HT2C receptor gene.Semantic proximity Read ↗

Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients.Semantic proximity Read ↗

5HT2C CYS23/SER23 polymorphism is not associated with obsessive-compulsive disorder.Semantic proximity Read ↗

Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response.Semantic proximity Read ↗

Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine.Semantic proximity Read ↗

Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine.Semantic proximity Read ↗

Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).Semantic proximity Read ↗

HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses.Semantic proximity Read ↗

Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia.Semantic proximity Read ↗

Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder.Semantic proximity Read ↗

Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability.Semantic proximity Read ↗

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