Article
Neutral mutations to three acidic AF2 residues in the mouse estrogen receptor confer agonist activity to A-ring isomers of estradiol.
The Journal of steroid biochemistry and molecular biology - 1 Jun 1997
Schwartz J A, Brooks S C
Abstract excerpt
The ability of the estrogen receptor (ER) to function as a ligand-mediated transcription factor involves the activation function-2 (AF2) in the hormone binding domain (HBD). Although several types of ligand bind to the ER, AF2 functions selectively, as it is activated by estradiol (E2) but not by...
Topics
- Animals
- Binding Sites
- Estradiol
- Mice
- Mutation
- Receptors, Estrogen
- Transcription, Genetic