Article
Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.
Cancer research - 15 Jan 1992
Fuqua S A, Fitzgerald S D, Allred D C, Elledge R M, Nawaz Z, McDonnell D P, O'Malley B W, Greene G L, McGuire W L
Abstract excerpt
It is fairly well accepted that the presence of estrogen receptor (ER) and progesterone receptor (PgR) identifies breast cancer patients with a lower risk of relapse and better overall survival. But patients with discordant receptors, the ER+/PgR- phenotype, are often intermediate in clinical response. We focused upon this group of patients and have identified a truncated ER which is abundant in some ER+/PgR-...
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