Article
Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.
Cancer research - 15 Jan 1992
Fuqua S A, Fitzgerald S D, Allred D C, Elledge R M, Nawaz Z, McDonnell D P, O'Malley B W, Greene G L, McGuire W L
Abstract excerpt
It is fairly well accepted that the presence of estrogen receptor (ER) and progesterone receptor (PgR) identifies breast cancer patients with a lower risk of relapse and better overall survival. But patients with discordant receptors, the ER+/PgR- phenotype, are often intermediate in clinical res...
Topics
- Base Sequence
- Breast Neoplasms
- DNA-Binding Proteins
- Exons
- Gene Expression Regulation, Neoplastic
- Genes, Dominant
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Receptors, Estrogen
- Receptors, Progesterone
- Transcription Factors
- Transcription, Genetic