Article
Evidence for genetic heterogeneity in inflammatory bowel disease (IBD); HLA genes in the predisposition to suffer from ulcerative colitis (UC) and Crohn's disease (CD).
Clinical and experimental immunology - 1 Jul 1997
Bouma G, Oudkerk Pool M, Crusius J B, Schreuder G M, Hellemans H P, Meijer B U, Kostense P J, Giphart M J, Meuwissen S G, Peña A S
Abstract excerpt
Family and epidemiological studies support a genetic susceptibility to UC and CD. Conflicting reports regarding associations between UC and HLA-DR2 and between CD and various HLA alleles have been published. The aim of this study was to determine whether molecularly defined HLA-DR genes are associated with these diseases in a Dutch group of patients. Fifty-nine unrelated Dutch UC patients and 89 CD patients were...
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