Evidence for genetic heterogeneity in inflammatory bowel disease (IBD); HLA genes in the predisposition to suffer from ulcerative colitis (UC) and Crohn's disease (CD).

doi:10.1046/j.1365-2249.1997.4121510.x

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Article

Evidence for genetic heterogeneity in inflammatory bowel disease (IBD); HLA genes in the predisposition to suffer from ulcerative colitis (UC) and Crohn's disease (CD).

Clinical and experimental immunology - 1 Jul 1997

Bouma G, Oudkerk Pool M, Crusius J B, Schreuder G M, Hellemans H P, Meijer B U, Kostense P J, Giphart M J, Meuwissen S G, Peña A S

Abstract excerpt

Family and epidemiological studies support a genetic susceptibility to UC and CD. Conflicting reports regarding associations between UC and HLA-DR2 and between CD and various HLA alleles have been published. The aim of this study was to determine whether molecularly defined HLA-DR genes are assoc...

Topics

Adolescent
Adult
Aged
Alleles
Child
Colitis, Ulcerative
Crohn Disease
DNA
Female
HLA-DR Antigens
Humans
Male
Middle Aged
Netherlands
Polymerase Chain Reaction

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Identifiers

PMID: 9218841
DOI: 10.1046/j.1365-2249.1997.4121510.x
PMCID: PMC1904705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9218841-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.