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Article

Genetic contribution to radiographic severity in osteoarthritis of the knee.

Annals of the rheumatic diseases - 1 Sept 2012

Valdes Ana M, Doherty Sally, Muir Kenneth R, Zhang Weiya, Maciewicz Rose A, Wheeler Margaret, Arden Nigel, Cooper Cyrus, Doherty M

Abstract excerpt

OBJECTIVE: Knee osteoarthritis (OA) has a significant genetic component. The authors have assessed the role of three variants reported to influence risk of knee OA with p<5×10-8 in determining patellofemoral and tibiofemoral Kellgren Lawrence (K/L) grade in knee OA cases. METHODS: 3474 knee OA cases with sky-line and weight-bearing antero-posterior x-rays of the knee were selected based on the presentation of K/L...

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Identifiers

PMID: 22615457
DOI: 10.1136/annrheumdis-2012-201382
PMCID: PMC3414227

Genes

GDF5
COG5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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