Article
Genome-wide association study for radiographic vertebral fractures: a potential role for the 16q24 BMD locus.
Bone - 1 Feb 2014
Oei Ling, Estrada Karol, Duncan Emma L, Christiansen Claus, Liu Ching-Ti, Langdahl Bente L, Obermayer-Pietsch Barbara, Riancho José A, Prince Richard L, van Schoor Natasja M, McCloskey Eugene, Hsu Yi-Hsiang, Evangelou Evangelos, Ntzani Evangelia, Evans David M, Alonso Nerea, Husted Lise B, Valero Carmen, Hernandez Jose L, Lewis Joshua R, Kaptoge Stephen K, Zhu Kun, Cupples L Adrienne, Medina-Gómez Carolina, Vandenput Liesbeth, Kim Ghi Su, Hun Lee Seung, Castaño-Betancourt Martha C, Oei Edwin H G, Martinez Josefina, Daroszewska Anna, van der Klift Marjolein, Mellström Dan, Herrera Lizbeth, Karlsson Magnus K, Hofman Albert, Ljunggren Östen, Pols Huibert A P, Stolk Lisette, van Meurs Joyce B J, Ioannidis John P A, Zillikens M Carola, Lips Paul, Karasik David, Uitterlinden André G, Styrkarsdottir Unnur, Brown Matthew A, Koh Jung-Min, Richards J Brent, Reeve Jonathan, Ohlsson Claes, Ralston Stuart H, Kiel Douglas P, Rivadeneira Fernando
Abstract excerpt
Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged > 55 years; and comprising 329 cases and 2666 controls with radiographic scoring...
Read the complete abstract on PubMed