Article
Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women.
Arthritis and rheumatism - 1 Jul 2003
Bergink Arjan P, van Meurs Joyce B, Loughlin John, Arp Pascal P, Fang Yue, Hofman Albert, van Leeuwen Johannes P T M, van Duijn Cornelia M, Uitterlinden André G, Pols Huibert A P
Abstract excerpt
OBJECTIVE: Genetic influences have been shown to play an important role in the etiology of osteoarthritis (OA), but the genes involved are ill-defined. We studied the association between polymorphisms in the estrogen receptor alpha (ERalpha) gene and the prevalence of radiographic OA of the knee. METHODS: The study group comprised 1,483 men and women from the Rotterdam Study. Direct molecular haplotyping was used...
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