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Article

Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia

1 May 1993

Abstract excerpt

Apolipoprotein (apo) E3-Leiden, described in a large Dutch family, is associated with a dominantly inherited form of familial dysbetalipoproteinemia. To study the effect of the APOE*3-Leiden mutation in vivo, transgenic mice were generated using a genomic 27-kilobase DNA construct isolated from the APOE*3-Leiden proband. This construct carried the APOE gene, the APOC1 gene, and all known regulatory elements...

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Identifiers

PMID: 7683682
DOI: 10.1016/s0021-9258(18)82232-3

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