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Article

Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export.

Molecular and cellular biology - 1 Dec 2000

Yoon J H, Love D C, Guhathakurta A, Hanover J A, Dhar R

Abstract excerpt

We identified the Schizosaccharomyces pombe mex67 gene (spmex67) as a multicopy suppressor of rae1-167 nup184-1 synthetic lethality and the rae1-167 ts mutation. spMex67p, a 596-amino-acid-long protein, has considerable sequence similarity to the Saccharomyces cerevisiae Mex67p (scMex67p) and human Tap. In contrast to scMEX67, spmex67 is essential for neither growth nor nuclear export of mRNA. However, an spmex67...

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Identifiers

PMID: 11073978
DOI: 10.1128/MCB.20.23.8767-8782.2000
PMCID: PMC86506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export.PMID 11073978Read ↗

Schizosaccharomyces pombe nup97, which Genetically Interacts with mex67, is essential for growth and involved in mRNA export.Semantic proximity Read ↗

A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor.Semantic proximity Read ↗

Conserved nuclear export sequences in Schizosaccharomyces pombe Mex67 and human TAP function in mRNA export by direct nuclear pore interactions.Semantic proximity Read ↗

Schizosaccharomyces pombe rsm1 genetically interacts with spmex67, which is involved in mRNA export.Semantic proximity Read ↗

Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores.Semantic proximity Read ↗

Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.Semantic proximity Read ↗

Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores.Semantic proximity Read ↗

Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export.Semantic proximity Read ↗

The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim.Semantic proximity Read ↗

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export.Semantic proximity Read ↗

Isolation of a novel rmn1 gene genetically linked to spnab2 with respect to mRNA export in fission yeast.Semantic proximity Read ↗

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.Semantic proximity Read ↗

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