Article
The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 1997
Zhu Q, Hulen D, Liu T, Clarke M
Abstract excerpt
The cluA gene of Dictyostelium discoideum encodes a novel 150-kDa protein. Disruption of cluA results in clustering of mitochondria near the cell center. This is a striking difference from normal cells, whose mitochondria are dispersed uniformly throughout the cytoplasm. The mutant cell populations also exhibit an increased frequency of multinucleated cells, suggesting an impairment in cytokinesis. Both...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Dictyostelium
- Fungal Proteins
- Mitochondria
- Molecular Sequence Data
- Mutation
- Proteins
- Protozoan Proteins