Article
The Parkinson's disease-associated protein DJ-1 plays a positive nonmitochondrial role in endocytosis in Dictyostelium cells.
Disease models & mechanisms - 1 Oct 2017
Chen Suwei, Annesley Sarah J, Jasim Rasha A F, Musco Vanessa J, Sanislav Oana, Fisher Paul R
Abstract excerpt
The loss of function of DJ-1 caused by mutations in DJ1 causes a form of familial Parkinson's disease (PD). However, the role of DJ-1 in healthy and in PD cells is poorly understood. Even its subcellular localization in mammalian cells is uncertain, with both cytosolic and mitochondrial locations having been reported. We show here that DJ-1 is normally located in the cytoplasm in healthy Dictyostelium discoideum...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.