Article
Loss of the F-actin binding and vesicle-associated protein comitin leads to a phagocytosis defect.
Eukaryotic cell - 1 Dec 2002
Schreiner Thomas, Mohrs Martina R, Blau-Wasser Rosemarie, von Krempelhuber Alfred, Steinert Michael, Schleicher Michael, Noegel Angelika A
Abstract excerpt
Comitin is an F-actin binding and membrane-associated protein from Dictyostelium discoideum, which is present on Golgi and vesicle membranes and changes its localization in response to agents affecting the cytoskeleton. To investigate its in vivo functions we have generated knockout mutants by gene replacement. Based on comitin's in vitro functions we examined properties related to vesicular transport and...
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