Article
Ndufaf5 deficiency in the Dictyostelium model: new roles in autophagy and development.
Molecular biology of the cell - 1 May 2013
Carilla-Latorre Sergio, Annesley Sarah J, Muñoz-Braceras Sandra, Fisher Paul R, Escalante Ricardo
Abstract excerpt
Ndufaf5 (also known as C20orf7) is a mitochondrial complex I (CI) assembly factor whose mutations lead to human mitochondrial disease. Little is known about the function of the protein and the cytopathological consequences of the mutations. Disruption of Dictyostelium Ndufaf5 leads to CI deficiency and defects in growth and development. The predicted sequence of Ndufaf5 contains a putative methyltransferase...
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