Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3

Abstract excerpt

Integrins are heterodimeric cell surface adhesion and signaling receptors that are essential for metazoan existence. Some integrins contain an I-domain that is a major ligand binding site. The ligands preferentially engage the active forms of the integrins and trigger signaling cascades that alter numerous cell functions. Here we found that the adenylate cyclase toxin (CyaA), a key virulence factor of the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacterial Infections and Vaccines
• Share to Biochemical and Structural Characterization
• Share to Streptococcal Infections and Treatments