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Article

Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast.

The Journal of cell biology - 30 Jun 1997

Longo V D, Ellerby L M, Bredesen D E, Valentine J S, Gralla E B

Abstract excerpt

We expressed the human anti-apoptotic protein, Bcl-2, in Saccharomyces cerevisiae to investigate its effects on antioxidant protection and stationary phase survival. Yeast lacking copper-zinc superoxide dismutase (sod1Delta) show a profound defect in entry into and survival during stationary phas...

Topics

Gene Expression Regulation, Fungal
Gene Transfer Techniques
Humans
Mutation
Oxidative Stress
Proto-Oncogene Proteins c-bcl-2
Saccharomyces cerevisiae
Superoxide Dismutase

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9199172
DOI: 10.1083/jcb.137.7.1581
PMCID: PMC2137818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9199172-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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