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Article

Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism.

The Journal of biological chemistry - 22 Nov 2002

Vander Heiden Matthew G, Choy John S, VanderWeele David J, Brace Jennifer L, Harris Marian H, Bauer Daniel E, Prange Bryan, Kron Stephen J, Thompson Craig B, Rudin Charles M

Abstract excerpt

All eukaryotic organisms have mechanisms to adapt to changing metabolic conditions. The mammalian cell survival gene Bcl-x(L) enables cells to adapt to changes in cellular metabolism. To identify genes whose function can be substituted by Bcl-x(L) in a unicellular eukaryote, a genetic screen was performed using the yeast Saccharomyces cerevisiae. S. cerevisiae grows by anaerobic glycolysis when glucose is...

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PMID: 12244097
DOI: 10.1074/jbc.M204888200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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