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Article

The Bcl-2 oncoprotein functions as a pro-oxidant.

The Journal of biological chemistry - 24 Feb 1995

Steinman H M

Abstract excerpt

The mechanism by which the bcl-2 oncogene exerts its anti-apoptotic and antioxidant action is unknown. We found that expression of bcl-2 in superoxide dismutase-deficient (SOD-) Escherichia coli resulted in increased transcription of the KatG catalase-peroxidase, a 13-fold increase in KatG activity and a 100-fold increase in resistance to hydrogen peroxide. In addition, mutation rate was increased 3-fold, and...

Topics

Animals
Antioxidants
Apoptosis
Bacterial Proteins
Catalase
Enzyme Induction
Escherichia coli
Escherichia coli Proteins
Hydrogen Peroxide
Mice
Oxidants
Peroxidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-bcl-2

Reactive Oxygen Species

Tumor Cells, Cultured

Source

Identifiers

PMID: 7876080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7876080-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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