Article
IgH and TcR-gamma gene rearrangements identified in Hodgkin's disease by PCR demonstrate lack of correlation between genotype, phenotype, and Epstein-Barr virus status.
The Journal of pathology - 1 Apr 1997
Al Saati T, Galoin S, Gravel S, Lamant L, Roda D, Chittal S M, Delsol G
Abstract excerpt
Analysis of IgH and TcR-gamma genes using consensus primers identifying junctional regions of rearranged genes by polymerase chain reaction (PCR) was performed on tissues involved by Hodgkin's disease (HD) in 90 cases and was correlated with the immunophenotype of Hodgkin and Reed-Sternberg (HRS) cells and the presence of Epstein-Barr virus (EBV) within these cells. Clonal IgH gene rearrangements were found in...
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