Hodgkin and reed-sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription.

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Article

Hodgkin and reed-sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription.

Blood - 15 Feb 2000

Marafioti T, Hummel M, Foss H D, Laumen H, Korbjuhn P, Anagnostopoulos I, Lammert H, Demel G, Theil J, Wirth T, Stein H

Abstract excerpt

Single cell studies aimed at clarifying the nature and clonality of Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin's disease (HD) have so far produced conflicting results. Using an improved single cell procedure, the HRS cells of 25 patients with nodular sclerosing HD lacking B- and T-cell antigens, with and without Epstein-Barr virus infection, were analyzed for the presence of immunoglobulin (Ig)...

Topics

Adolescent
Adult
Aged
B-Lymphocytes
Child
Clone Cells
Female
Gene Rearrangement, B-Lymphocyte
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Gene Rearrangement, B-Lymphocyte, Light Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Immunoglobulin

Hodgkin Disease

Humans

Immunoglobulin Heavy Chains

Immunoglobulin Light Chains

Male

Middle Aged

Mutation

Source

Open in PubMed

Identifiers

PMID: 10666223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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