Article
Hodgkin's disease with a B-cell phenotype often shows a VDJ rearrangement and somatic mutations in the VH genes.
Blood - 1 Aug 1994
Tamaru J, Hummel M, Zemlin M, Kalvelage B, Stein H
Abstract excerpt
The nature of Hodgkin and Reed-Sternberg (HRS) cells remains in question. Immunophenotypic studies favor a relation to the lymphoid lineage with the existence of B- and T-cell types. However, studies on the detection of antigen (Ag) receptor gene rearrangements provided inconsistent results. They...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Clone Cells
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Hodgkin Disease
- Humans
- Immunoglobulin Heavy Chains
- Immunologic Memory
- Immunophenotyping
- Lymphoma, B-Cell
- Lymphoma, Non-Hodgkin
- Molecular Sequence Data
- Mutation
- Sequence Alignment
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid