Article
Somatic mutations within the untranslated regions of rearranged Ig genes in a case of classical Hodgkin's disease as a potential cause for the absence of Ig in the lymphoma cells.
Blood - 1 Jun 1999
Jox A, Zander T, Küppers R, Irsch J, Kanzler H, Kornacker M, Bohlen H, Diehl V, Wolf J
Abstract excerpt
Hodgkin-Reed-Sternberg (H-RS) cells are clonal B cells carrying Ig gene rearrangements. However, in situ hybridization methods failed to demonstrate Ig gene expression in H-RS cells of classical Hodgkin's disease (HD). Because somatic mutations rendering potentially functional Ig gene rearrangements nonfunctional were detected in some cases of the disease, it was speculated that H-RS cells in classical HD may...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.