Article
Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.
Proceedings of the National Academy of Sciences of the United States of America - 8 Nov 1994
Küppers R, Rajewsky K, Zhao M, Simons G, Laumann R, Fischer R, Hansmann M L
Abstract excerpt
Hodgkin disease (HD) is characterized by a small number of putative malignant cells [Hodgkin and Reed-Sternberg (HRS) cells] among a background of lymphocytes and histiocytes. The lineage of HRS cells is still elusive and a clonal origin of these rare cells has not formally been demonstrated. We isolated HRS cells by micromanipulation from histological sections of three cases of Hodgkin lymphoma (each...
Topics
- Adult
- Aged
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Clone Cells
- Gene Expression Regulation, Developmental
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Rearrangement, B-Lymphocyte, Light Chain