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Article

Relaxation of imprinting of the insulin-like growth factor II gene in colorectal cancer.

Cancer letters - 1 Oct 1996

Kinouchi Y, Hiwatashi N, Higashioka S, Nagashima F, Chida M, Toyota T

Abstract excerpt

The insulin-like growth factor II gene (IGF2) is imprinted in normal human tissues, and relaxation of imprinting (ROI) of IGF2 is thought to play an important role in human childhood tumors. Taking advantage of an Apa I polymorphism in this gene, allelic expression of IGF2 has now been examined in colorectal cancer. Thirteen of 33 patients studied were informative. Colorectal cancer tissue from 5 of the 13...

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Source

Identifiers

PMID: 8913273
DOI: 10.1016/0304-3835(96)04348-0

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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