Article
Role of the p53 tumor suppressor gene in the tumorigenicity of Burkitt's lymphoma cells.
Cancer research - 15 Jun 1997
Cherney B W, Bhatia K G, Sgadari C, Gutierrez M I, Mostowski H, Pike S E, Gupta G, Magrath I T, Tosato G
Abstract excerpt
Burkitt's lymphoma (BL) cell lines carry a translocated c-myc gene and, in 60-80% of cases, exhibit mutations in the p53 tumor suppressor gene. We examined the potential role of the p53 gene in BL tumorigenicity using an in vitro assay that measures p53-dependent cell cycle arrest in the G1 phase of the cell cycle and an in vivo athymic murine model that detects differences in the tumorigenicity of BL cell lines....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.