Article
p53 is frequently mutated in Burkitt's lymphoma cell lines.
The EMBO journal - 1 Oct 1991
Farrell P J, Allan G J, Shanahan F, Vousden K H, Crook T
Abstract excerpt
A panel of 12 Burkitt's lymphoma cell lines and four other B cell lines were tested for the presence of mutations in p53. Protein analysis using a mutant-specific antibody and sequencing of both cDNA and genomic DNA revealed changes relative to the standard p53 protein sequence in 12 of the 16 li...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Blotting, Western
- Burkitt Lymphoma
- DNA
- DNA, Neoplasm
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Precipitin Tests
- RNA, Neoplasm
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53