Dwarfism and age-associated spinal degeneration of heterozygote <i>cmd</i> mice defective in aggrecan

Abstract excerpt

Mouse cartilage matrix deficiency (cmd) is an autosomal recessive disorder caused by a genetic defect of aggrecan, a large chondroitin sulfate proteoglycan in cartilage. The homozygotes (-/-) are characterized by cleft palate and short limbs, tail, and snout. They die just after birth because of respiratory failure, and the heterozygotes (+/-) appear normal at birth. Here we report that the heterozygotes show...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Osteoarthritis Treatment and Mechanisms
• Share to Protease and Inhibitor Mechanisms
• Share to Proteoglycans and glycosaminoglycans research