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Article

Protein consequences of the Col2a1 C-propeptide mutation in the chondrodysplastic Dmm mouse.

Matrix biology : journal of the International Society for Matrix Biology - 1 Sept 2003

Fernandes Russell J, Seegmiller Robert E, Nelson Whitney R, Eyre David R

Abstract excerpt

The Disproportionate micromelia (Dmm) mouse has a three nucleotide deletion in Col2a1 in the region encoding the C-propeptide which results in the substitution of one amino acid, Asn, for two amino acids, Lys-Thr. Western blot and immunohistochemical analyses failed to detect type II collagen in the cartilage matrix of the homozygous mice and showed reduced levels in the matrix of heterozygous mice. Type II...

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PMID: 14614991
DOI: 10.1016/s0945-053x(03)00077-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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