Article
Spondylometaphyseal dysplasia in mice carrying a dominant negative mutation in a matrix protein specific for cartilage-to-bone transition.
Nature - 2 Sept 1993
Jacenko O, LuValle P A, Olsen B R
Abstract excerpt
The vertebrate skeleton is formed primarily by endochondral ossification, starting during embryogenesis when cartilage anlagens develop central regions of hypertrophic cartilage which are replaced by bony trabeculae and bone marrow. During this process chondrocytes express a unique matrix molecul...
Topics
- Animals
- Base Sequence
- Bone and Bones
- Cartilage
- Chickens
- Collagen
- DNA
- Genes, Dominant
- Immunoenzyme Techniques
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Osteochondrodysplasias
- Osteogenesis
- Radiography
- Restriction Mapping