Article

Human hip osteoarthritis–associated <i>Chadl</i> variant induces intervertebral disc degeneration in mice

2026-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Chondroadherin-like (CHADL), a small leucine-rich proteoglycan, plays a role in ECM assembly and chondrocyte differentiation. CHADL has been implicated in osteoarthritis (OA) due to the discovery of a rare frameshift variant (rs532464664) that confers one of the highest genetic risks for hip OA reported to date. In this study, we characterized the skeletal phenotypes of two mouse models of Chad...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4fdead75-b65c-526a-894b-559a04b10149
DOI: 10.64898/2026.06.04.730159

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human hip osteoarthritis–associated <i>Chadl</i> variant induces intervertebral disc degeneration in miceDOI 10.64898/2026.06.04.730159Read

Tendon and Motor Phenotypes in the <i> Crtap <sup>-/-</sup> </i> Mouse Model of Recessive Osteogenesis ImperfectaSemantic proximity Read

Dwarfism and age-associated spinal degeneration of heterozygote <i>cmd</i> mice defective in aggrecanSemantic proximity Read

Identification of KANSL1 as a novel pathogenic gene for developmental dysplasia of the hip.Semantic proximity Read

Etiology of osteoarthritis: genetics and synovial joint development.Semantic proximity Read

Lessons from genetic forms of osteoarthritis for the pathogenesis of the disease.Semantic proximity Read

Abnormal craniofacial and spinal bone development with <i>col2a1</i> a depletion in a zebrafish model of CHARGE syndromeSemantic proximity Read

Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging.Semantic proximity Read

Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model.Semantic proximity Read

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J miceSemantic proximity Read

3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc diseaseSemantic proximity Read

Comprehensive analysis of N6-methyladenosine (m6A) modification during the degeneration of lumbar intervertebral disc in miceSemantic proximity Read

Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.Semantic proximity Read