Article
Development of high-grade renal cell carcinomas in rats independently of somatic mutations in the Tsc2 and VHL tumor suppressor genes.
Japanese journal of cancer research : Gann - 1 Aug 1998
Toyokuni S, Okada K, Kondo S, Nishioka H, Tanaka T, Nishiyama Y, Hino O, Hiai H
Abstract excerpt
Ferric nitrilotriacetate (Fe-NTA) induces renal proximal tubular damage that ultimately leads to a high incidence of renal cell carcinoma (RCC) in rats. The RCCs are characterized by 1) high incidence of pulmonary metastasis and peritoneal invasion, 2) high incidence of tumor-associated mortality...
Topics
- Animals
- Base Sequence
- Carcinogens
- Carcinoma, Renal Cell
- Exons
- Female
- Ferric Compounds
- Genes, Tumor Suppressor
- Kidney Neoplasms
- Male
- Molecular Sequence Data
- Mutagens
- Mutation
- Nitrilotriacetic Acid
- Polymerase Chain Reaction