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Article

Myogenic stem cell function is impaired in mice lacking the <i>forkhead</i> /winged helix protein MNF

2 May 2000

Abstract excerpt

Myocyte nuclear factor (MNF) is a winged helix transcription factor that is expressed selectively in myogenic stem cells (satellite cells) of adult animals. Using a gene knockout strategy to generate a functional null allele at the Mnf locus, we observed that mice lacking MNF are viable, but severely runted. Skeletal muscles of Mnf-/- animals are atrophic, and satellite cell function is impaired. Muscle...

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PMID: 10792059
DOI: 10.1073/pnas.100501197

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