Article
Molecular signatures of anti-nuclear antibodies: contributions of specific light chain residues and a novel New Zealand Black V kappa 1 germline gene.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2003
Liang Zhiyan, Chen Cui, Mohan Chandra
Abstract excerpt
Although the Ig H chains of anti-nuclear Abs (ANA) have been described to possess certain shared molecular signatures, it remains unclear whether the L chains of these Abs also possess distinctive molecular features. The present study examines this by generating and analyzing two comprehensive murine Ig L chain databases, one consisting of 264 monoclonal ANAs and the other consisting of 145 non-ANAs, drawn from...
Topics
- Animals
- Antibodies, Antinuclear
- Antibody Diversity
- DNA, Single-Stranded
- Databases, Genetic
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Immunoglobulin Joining Region
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region