Article
Widespread neuronal ectopia associated with secondary defects in cerebrocortical chondroitin sulfate proteoglycans and basal lamina in MARCKS-deficient mice.
Experimental neurology - 1 May 1997
Blackshear P J, Silver J, Nairn A C, Sulik K K, Squier M V, Stumpo D J, Tuttle J S
Abstract excerpt
Mice deficient in MARCKS, a prominent neural substrate for protein kinase C (PKC), die before or shortly after birth. They exhibit high frequencies of exencephaly, universal agenesis of forebrain commissures, and abnormalities of cerebral cortical and retinal lamination. We show here that these m...
Topics
- Animals
- Antibodies, Monoclonal
- Basement Membrane
- Cerebral Cortex
- Chondroitin Sulfates
- Female
- Gene Expression Regulation, Developmental
- Intracellular Signaling Peptides and Proteins
- Laminin
- Male
- Membrane Proteins
- Mice
- Mice, Mutant Strains
- Microscopy, Electron, Scanning