Primary cellular meningeal defects cause neocortical dysplasia and dyslamination.

doi:10.1002/ana.22103

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Article

Primary cellular meningeal defects cause neocortical dysplasia and dyslamination.

Annals of neurology - 1 Oct 2010

Hecht Jonathan H, Siegenthaler Julie A, Patterson Katelin P, Pleasure Samuel J

Abstract excerpt

OBJECTIVE: Cortical malformations are important causes of neurological morbidity, but in many cases their etiology is poorly understood. Mice with Foxc1 mutations have cellular defects in meningeal development. We use hypomorphic and null alleles of Foxc1 to study the effect of meningeal defects on neocortical organization. METHODS: Embryos with loss of Foxc1 activity were generated using the hypomorphic...

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Identifiers

PMID: 20976766
DOI: 10.1002/ana.22103
PMCID: PMC2966036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.