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Article

Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation.

The Journal of cell biology - 9 Jul 2001

Moré M I, Kirsch F P, Rathjen F G

Abstract excerpt

The NgCAM-related cell adhesion molecule (NrCAM) is an immunoglobulin superfamily member of the L1 subgroup that interacts intracellularly with ankyrins. We reveal that the absence of NrCAM causes the formation of mature cataracts in the mouse, whereas significant pathfinding errors of commissural axons at the midline of the spinal cord or of proprioceptive axon collaterals are not detected. Cataracts, the most...

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Share to Ankyrins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11449000
DOI: 10.1083/jcb.200104038
PMCID: PMC2196853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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