Article
Consistent allelic loss on mouse chromosome 7 distal to tyrosinase in 4-nitroquinoline-1-oxide-induced oral cavity tumors with loss of heterozygosity at Ha-ras-1.
Molecular carcinogenesis - 1 May 1997
Yuan B, Hu L H, Lentsch E M, Shum-Siu A, Hendler F J
Abstract excerpt
We have previously shown that all CBA/J mice exposed to 4-nitroquinoline-1-oxide (4NQO) eventually develop oral cavity squamous cell carcinomas, and two-thirds of these tumors have Ha-ras-1 (Hras1) point mutations at codon 12. Half of the tumors with Hras1 mutations have loss of heterozygosity (L...
Topics
- 4-Nitroquinoline-1-oxide
- Alleles
- Animals
- Base Sequence
- Carcinogens
- Carcinoma, Squamous Cell
- Chromosomes
- Gene Deletion
- Genes, ras
- Hemoglobins
- Heterozygote
- Macromolecular Substances
- Mice
- Mice, Inbred CBA
- Molecular Sequence Data
- Monophenol Monooxygenase
- Mouth Neoplasms