Article
T cell receptor Ddelta2Ddelta3 rearrangement: a suitable allele-specific marker for the detection of minimal residual disease in childhood acute lymphoblastic leukemia.
Leukemia - 1 May 1997
Seriu T, Erz D, Stark Y, Bartram C R
Abstract excerpt
The applicability of T cell receptor (TCR) Ddelta2Ddelta3 junctional regions for the detection of minimal residual disease (MRD) was examined in childhood acute lymphoblastic leukemia (ALL). Southern blot analysis showed a Ddelta2Ddelta3 rearrangement in 22 of 172 (13%) precursor-B ALL. No Ddelta2Ddelta3 rearrangement was identified in 29 T-ALL cases. Three patients exhibited Ddelta2Ddelta3 recombinations in both...
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