Article
Human common acute lymphoblastic leukemia-derived cell lines are competent to recombine their T-cell receptor delta/alpha regions along a hierarchically ordered pathway.
Blood - 1 Nov 1992
Hansen-Hagge T E, Yokota S, Reuter H J, Schwarz K, Bartram C R
Abstract excerpt
Rearrangements of the T-cell receptor (TCR) delta locus are observed in the majority of human B-cell precursor acute lymphoblastic leukemias (ALL) with a striking predominance of V delta 2(D)D delta 3 recombinations in common ALL (cALL) patients. Recently, we and others showed that almost 20% of...
Topics
- Base Sequence
- Blotting, Southern
- Clone Cells
- Cloning, Molecular
- DNA, Neoplasm
- Genotype
- Humans
- Immunophenotyping
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Receptors, Antigen, T-Cell
- Recombination, Genetic
- Tumor Cells, Cultured