Article
Use of oligonucleotide probes directed against T cell antigen receptor gamma delta variable-(diversity)-joining junctional sequences as a general method for detecting minimal residual disease in acute lymphoblastic leukemias.
The Journal of clinical investigation - 1 Dec 1990
Macintyre E A, d'Auriol L, Duparc N, Leverger G, Galibert F, Sigaux F
Abstract excerpt
To provide a sensitive and generally applicable method to detect clonal cells in acute lymphoblastic leukemias (ALL), we have designed a new strategy based on the polymerase chain reaction (PCR) amplification of the T cell receptor gamma delta gene rearrangements found in most T and B lineage ALL...
Topics
- Alleles
- Base Sequence
- Clone Cells
- Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
- Humans
- Molecular Sequence Data
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, gamma-delta