T cell receptor gamma (TCRG) gene rearrangements in T cell acute lymphoblastic leukemia refelct 'end-stage' recombinations: implications for minimal residual disease monitoring.

doi:10.1038/sj.leu.2401765

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Article

T cell receptor gamma (TCRG) gene rearrangements in T cell acute lymphoblastic leukemia refelct 'end-stage' recombinations: implications for minimal residual disease monitoring.

Leukemia - 1 Jul 2000

Szczepański T, Langerak A W, Willemse M J, Wolvers-Tettero I L, van Wering E R, van Dongen J J

Abstract excerpt

The T cell receptor gamma (TCRG) gene configuration was established in a large series of 126 T cell acute lymphoblastic leukemia (T-ALL) patients using combined Southern blotting (SB) and heteroduplex PCR analyses. The vast majority of TALL (96%) displayed clonal TCRG gene rearrangements, with biallelic recombination in 91% of patients. A small immature subgroup of CD3- T-ALL (n = 5) had both TCRG genes in...

Topics

Adult
Alleles
Blotting, Southern
Child
Clone Cells
DNA, Neoplasm
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Heteroduplex Analysis
Humans
Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia-Lymphoma, Adult T-Cell

Neoplasm Proteins

Neoplasm, Residual

Neoplastic Stem Cells

Polymerase Chain Reaction

Receptors, Antigen, T-Cell, gamma-delta

Recombination, Genetic

T-Lymphocyte Subsets

Source

Open in PubMed

Identifiers

PMID: 10914544
DOI: 10.1038/sj.leu.2401765

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