Southern blot patterns, frequencies, and junctional diversity of T-cell receptor-delta gene rearrangements in acute lymphoblastic leukemia.

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Article

Southern blot patterns, frequencies, and junctional diversity of T-cell receptor-delta gene rearrangements in acute lymphoblastic leukemia.

Blood - 15 Nov 1993

Breit T M, Wolvers-Tettero I L, Beishuizen A, Verhoeven M A, van Wering E R, van Dongen J J

Abstract excerpt

Southern blot analysis of T-cell receptor (TCR)-delta gene rearrangements is useful for diagnostic studies on the clonality of lymphoproliferative diseases. We have developed 18 new TCR-delta gene probes by use of the polymerase chain reaction (PCR) techniques. Application of these probes for det...

Topics

Alleles
Base Sequence
Blotting, Southern
Gene Deletion
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
Humans
Molecular Sequence Data
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Restriction Mapping

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Open in PubMed

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PMID: 8219197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8219197-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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