Article
Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis.
Blood - 15 Apr 2008
Balgobind Brian V, Van Vlierberghe Pieter, van den Ouweland Ans M W, Beverloo H Berna, Terlouw-Kromosoeto Joan N R, van Wering Elisabeth R, Reinhardt Dirk, Horstmann Martin, Kaspers Gertjan J L, Pieters Rob, Zwaan C Michel, Van den Heuvel-Eibrink Marry M, Meijerink Jules P P
Abstract excerpt
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder caused by mutations in the NF1 gene. Patients with NF1 have a higher risk to develop juvenile myelomonocytic leukemia (JMML) with a possible progression toward acute myeloid leukemia (AML). In an oligo array comparative geno...
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