Article
Absence of RET proto-oncogene mutations in a father and son with pheochromocytoma and pancreatic islet cell tumor.
International journal of urology : official journal of the Japanese Urological Association - 1 Mar 1997
Kawasaki T, Tomita Y, Takahashi H, Takeda M, Tanaka H, Tamiya Y, Takahashi K
Abstract excerpt
BACKGROUND: We describe a father and son with a combination of pheochromocytoma and pancreatic islet cell tumor. Although its familial occurrence is rare, this syndrome could be called overlapping-type multiple endocrine neoplasia (MEN), since it fulfills the criteria for both type 1 and type 2 MEN. Recently, germ line mutations of the RET proto-oncogene (RET) were found to be related to tumorigenesis and disease...
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