Clinical presentations and RET protooncogene mutations in seven multiple endocrine neoplasia type 2 kindreds.

Article

Clinical presentations and RET protooncogene mutations in seven multiple endocrine neoplasia type 2 kindreds.

Cancer - 1 Nov 1996

Blank R D, Sklar C A, Dimich A B, LaQuaglia M P, Brennan M F

Abstract excerpt

BACKGROUND: Multiple endocrine neoplasia type 2 (MEN 2) is a group of related autosomal dominant cancer syndromes caused by mutations in the RET protooncogene. A subset of familial Hirschsprung's disease, aganglionic megacolon, is also caused by mutations in this gene. METHODS: The authors perfor...

Topics

Adult
Child
Family
Female
Hirschsprung Disease
Humans
Male
Middle Aged
Multiple Endocrine Neoplasia Type 2a
Mutation
Oncogene Proteins
Pedigree
Proto-Oncogene Proteins c-ret
Proto-Oncogenes
Receptor Protein-Tyrosine Kinases

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