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Article

A novel case of multiple endocrine neoplasia type 2A associated with two de novo mutations of the RET protooncogene.

The Journal of clinical endocrinology and metabolism - 1 Oct 1999

Tessitore A, Sinisi A A, Pasquali D, Cardone M, Vitale D, Bellastella A, Colantuoni V

Abstract excerpt

We report a novel case of multiple endocrine neoplasia type 2A (MEN 2A) associated with two mutations of the protooncogene RET. One affects codon 634 and causes a cysteine to arginine substitution; the second at codon 640 causes an alanine to glycine substitution in the transmembrane region. The two mutations were present on the same RET allele and were detected in germline and tumor DNA. Both mutations were de...

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Source

Identifiers

PMID: 10522989
DOI: 10.1210/jcem.84.10.6056

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel case of multiple endocrine neoplasia type 2A associated with two de novo mutations of the RET protooncogene.PMID 10522989Read ↗

De novo mutation of the RET proto-oncogene revealing multiple endocrine neoplasia type 2A: a sporadic case from Western Algeria.Semantic proximity Read ↗

[The molecular pathology of RET protooncogene in families with multiple endocrine neoplasia type 2A].Semantic proximity Read ↗

[A comparison of clinical characteristics between 2 pedigrees of multiple endocrine neoplasia type 2A with different RET mutations].Semantic proximity Read ↗

Impact of RET proto-oncogene analysis on the clinical management of multiple endocrine neoplasia type 2.Semantic proximity Read ↗

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

Multiple endocrine neoplasia 2A with RET mutation p.Cys611Tyr: A case report.Semantic proximity Read ↗

Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC: two novel mutations and one de novo mutation for MEN 2A.Semantic proximity Read ↗

Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis.Semantic proximity Read ↗

Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene.Semantic proximity Read ↗

RET Cys634Arg mutation confers a more aggressive multiple endocrine neoplasia type 2A phenotype than Cys634Tyr mutation.Semantic proximity Read ↗

A newly detected mutation of the RET protooncogene in exon 8 as a cause of multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B.Semantic proximity Read ↗

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