Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun.

doi:10.1016/s0306-4522(96)00623-9

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Article

Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun.

Neuroscience - 1 Jun 1997

Hughes P E, Alexi T, Hefti F, Knusel B

Abstract excerpt

The inducible transcription factor c-Jun increases in neurons in response to axotomy by unknown mechanisms, and it has been postulated that c-Jun may regulate genes involved in promoting either degeneration or regeneration of axotomized neurons. In this report, we investigated the effect of daily...

Topics

Animals
Apoptosis
Axons
DNA Fragmentation
Denervation
Female
Frontal Lobe
Nerve Growth Factors
Neurons
Neuroprotective Agents
Parasympathetic Nervous System
Phenotype
Proto-Oncogene Proteins c-jun
Rats
Rats, Wistar
Septum Pellucidum

Source

Open in PubMed

Identifiers

PMID: 9174072
DOI: 10.1016/s0306-4522(96)00623-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9174072-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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