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Article

Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun.

Neuroscience - 1 Jun 1997

Hughes P E, Alexi T, Hefti F, Knusel B

Abstract excerpt

The inducible transcription factor c-Jun increases in neurons in response to axotomy by unknown mechanisms, and it has been postulated that c-Jun may regulate genes involved in promoting either degeneration or regeneration of axotomized neurons. In this report, we investigated the effect of daily or twice daily intraventricular administration of the neurotrophins nerve growth factor or neurotrophin-4/5 on the...

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PMID: 9174072
DOI: 10.1016/s0306-4522(96)00623-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun.PMID 9174072Read ↗

Neurotrophin-4/5 maintains the cholinergic phenotype of axotomized septal neurons.Semantic proximity Read ↗

BMP9 protects septal neurons from axotomy-evoked loss of cholinergic phenotype.Semantic proximity Read ↗

Cholinergic expression by a neural stem cell line grafted to the adult medial septum/diagonal band complex.Semantic proximity Read ↗

c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.Semantic proximity Read ↗

Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons.Semantic proximity Read ↗

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.Semantic proximity Read ↗

Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic neuronal phenotype in organotypic brain slices of the basal nucleus of Meynert.Semantic proximity Read ↗

Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons.Semantic proximity Read ↗

Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy.Semantic proximity Read ↗

Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons.Semantic proximity Read ↗

Evidence that brain-derived neurotrophic factor from presynaptic nerve terminals regulates the phenotype of calbindin-containing neurons in the lateral septum.Semantic proximity Read ↗

PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.Semantic proximity Read ↗

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