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Article

Neurotrophin-4/5 maintains the cholinergic phenotype of axotomized septal neurons.

The European journal of neuroscience - 1 Feb 1996

Alderson R F, Wiegand S J, Anderson K D, Cai N, Cho J Y, Lindsay R M, Altar C A

Abstract excerpt

We examined the effect of intraseptal or intracerebroventricular (i.c. v.) infusions of NT-4/5 or intraseptal infusions of NGF on the level of immunohistochemical staining of choline acetyltransferase (ChAT)and the low-affinity nerve growth factor receptor (LNGFR)in the rat medial septum following unilateral transection of the fimbria. The extent of cell loss in the septum ipsilateral to the lesion, determined by...

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Source

Identifiers

PMID: 8714699
DOI: 10.1111/j.1460-9568.1996.tb01212.x

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurotrophin-4/5 maintains the cholinergic phenotype of axotomized septal neurons.PMID 8714699Read ↗

BMP9 protects septal neurons from axotomy-evoked loss of cholinergic phenotype.Semantic proximity Read ↗

Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun.Semantic proximity Read ↗

Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons.Semantic proximity Read ↗

Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons.Semantic proximity Read ↗

Cholinergic expression by a neural stem cell line grafted to the adult medial septum/diagonal band complex.Semantic proximity Read ↗

Evidence that brain-derived neurotrophic factor from presynaptic nerve terminals regulates the phenotype of calbindin-containing neurons in the lateral septum.Semantic proximity Read ↗

Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9.Semantic proximity Read ↗

Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits.Semantic proximity Read ↗

Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic neuronal phenotype in organotypic brain slices of the basal nucleus of Meynert.Semantic proximity Read ↗

<i>TrkA</i>Gene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic CircuitrySemantic proximity Read ↗

Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus.Semantic proximity Read ↗

Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing.Semantic proximity Read ↗

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